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Author: oncologs.com

super-chilled-brain-cell-molecules-reveal-how-epilepsy-drug-works

Super-chilled brain cell molecules reveal how epilepsy drug works

FOR IMMEDIATE RELEASE Credit: Twomey lab, Johns Hopkins Medicine FOR IMMEDIATE RELEASE By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius — nearly twice as cold as the coldest places in Antarctica — scientists at Johns
rna-splicing’s-spotters

RNA splicing’s spotters

Bodybuilders and cellular mechanisms agree generating protein is a heavy lift. To complete the task, cells rely on complexes called spliceosomes. These molecular machines snip extra bits out of our genes’ RNA copies and piece together precise instructions for protein-building. When the splicing process goes
restoring-our-ubiquitination-machinery-to-overcome-resistance-to-cancer-therapy

Restoring our ubiquitination machinery to overcome resistance to cancer therapy

“[…] the identification of ubiquitin-conjugating enzymes like UBE2J1 and the innovative deployment of PROTAC-type androgen receptor degraders are crucial in combating prostate cancer and overcoming therapeutic resistance.” Credit: 2024 Li and Mu. “[…] the identification of ubiquitin-conjugating enzymes like UBE2J1 and the innovative deployment of
advancing-cancer-tracking:-difc-detects-rare-cells-noninvasively

Advancing cancer tracking: DiFC detects rare cells noninvasively

In the relentless fight against cancer, a new technology promises to shed light on how we track and understand the spread of this disease within the body. A research team from Northeastern University and Dartmouth College recently developed a remarkable tool called “diffuse in vivo flow cytometry”
decoding-salvia-miltiorrhiza:-a-molecular-approach-to-boosting-bioactive-compounds

Decoding salvia miltiorrhiza: a molecular approach to boosting bioactive compounds

Salvia miltiorrhiza, known as Danshen, is widely used in traditional Chinese medicine for treating cardiovascular diseases, cancer, and Alzheimer’s disease. The medicinal properties of Danshen are primarily attributed to its two major bioactive compounds: tanshinones and phenolic acids. Despite their importance, the genetic and regulatory
transfer-rnas-at-the-heart-of-therapeutic-resistance

Transfer RNAs at the heart of therapeutic resistance

An international research team led by scientists from the University of Liège has discovered an interesting new therapeutic target for the treatment of melanoma resistant to targeted therapies. Inhibition of the VARS enzyme could prevent this therapeutic resistance by resensitising tumours resistant to these targeted
study-identifies-potential-pathway-to-reducing-breast-cancer-brain-metastases

Study identifies potential pathway to reducing breast cancer brain metastases

A study led by researchers from the University of Arizona Cancer Center at UArizona Health Sciences identified a biological mechanism that could lead to more effective treatments for breast cancer that has metastasized to the brain. Credit: Photo by Kris Hanning, UArizona Health Sciences Office of Communications
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