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Potential new approach to enhancing stem-cell transplants

August 8, 2024—(BRONX NY)—A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body’s different blood

Fibroblast functionality: a pivotal piece in cancer’s spreading puzzle

A new study reviews how cancer-associated fibroblasts (CAFs) influence lymph node metastasis. Researchers identified various CAF subsets that interact with the tumor microenvironment, promoting cancer spread. By targeting these specific subsets, new therapeutic strategies can be developed to inhibit metastasis, potentially improving patient outcomes. This

Tpex cells: the game-changer in targeted tumor immunotherapy

Progenitor exhausted CD8+ T (Tpex) cells have emerged as a pivotal component in tumor immunotherapy due to their unique ability to self-renew and rapidly proliferate. These cells have shown promise in expanding and differentiating into functional exhausted CD8+ T cells, significantly enhancing clinical outcomes. Understanding

TCR CDR3s and renalase-1 linked to increased melanoma survival

“These findings indicate that renalase-1 is a potential antigen for TCR recognition in melanoma and could be considered as a target for immunotherapy.” Credit: 2024 Zaman et al. “These findings indicate that renalase-1 is a potential antigen for TCR recognition in melanoma and could be

Cannabis use tied to head and neck cancer

LOS ANGELES — A study from the USC Head and Neck Center, part of Keck Medicine of USC and the USC Caruso Department of Otolaryngology – Head and Neck Surgery, suggests that cannabis, the most commonly used illicit substance worldwide, is associated with an increased occurrence of

Insilico Medicine received IND approval and orphan drug designation from FDA for ISM6331, an AI-designed TEAD inhibitor targeting solid tumors and mesothelioma

CAMBRIDGE, Mass., Aug 8, 2024 — Insilico Medicine (“Insilico”), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced ISM6331, potential best-in-class pan-TEAD inhibitor, has received the U.S. Food and Drug Administration (FDA) Investigational New Drug (IND) clearance for the treatment of mesothelioma, following the

Dealing with runaway metastatic disease

BUFFALO, NY – August 7, 2024 – A new editorial paper was published in Oncotarget’s Volume 15 on July 12, 2024, entitled, “How to deal with runaway metastatic disease?” In this new editorial, Justine Paris and Guilhem Bousquet from Université Paris Cité, Université Sorbonne Paris
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