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An analysis of pre-treatment tumor specimens from 105 patients with localized muscle-invasive bladder cancer found that the presence of a mutation in any one of three genes, all known to be involved in DNA damage repair, was associated with complete pathologic response to cisplatin-based neoadjuvant

In a healthy human body, tissue growth and development are coordinated by many different mechanisms. Within our bodies, these mechanisms regulate the healthy growth of cells, limit their size and number, and control the timing of cell death through apoptosis. However, when these regulatory pathways

MIAMI, FLORIDA (July 25, 2024) – Many people with stage II or III colon cancer receive additional, or adjuvant, chemotherapy following surgery. However, clinical trials have shown that this treatment doesn’t improve the chances of survival for every patient. A study published July 25 in

“[…] we present the first study to retrospectively evaluate differential gene expression of MIF, DDT, and relevant pathway markers in regard to clinical outcomes in patients with melanoma.” Credit: 2024 Valdez et al. “[…] we present the first study to retrospectively evaluate differential gene expression

A combination of two drugs was capable of suppressing tumors in a non-conventional manner. Instead of inhibiting tumor cell division, as the most widely used medications do, the strategy consisted of hyperactivating oncogenic signaling by these cells to the point where they became stressed. The

MIAMI, FLORIDA (July 25, 2024) – Three junior faculty members at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have been named K12 2024 Faculty Scholars. They bring to 16 the number of junior faculty who have joined Sylvester’s

Chapel Hill, North Carolina—Researchers at UNC Lineberger Comprehensive Cancer Center and colleagues have determined that a specific type of immune cell — type II innate lymphoid cells (ILC2s) — can change its characteristics and functions after a cancer patient receives stem cells from a donor,

An experimental cancer drug could make thinking easier for individuals with Rett syndrome, a rare disorder linked to autism, according to new research from the University of California San Diego — a discovery that could lead to therapies for patients with other neurological conditions. Credit:

Peptides are gradually emerging as middle-sized therapeutic agents in addressing unmet medical needs. Compared to small-molecule drugs, peptides can target complex biological processes more precisely while generally less complex and more a cost-effective than large biological drugs like antibodies. Over 100 FDA-approved peptide drugs have

While chemotherapy has advanced in personalization, personalized radiation therapy for cancer remains underdeveloped. Current cancer treatment methods – including radiation therapy – are intricate, lack personalization, and rely heavily on the expertise of medical teams. Medical image analysis and machine learning hold great promise for