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Monoclonal antibodies are crucial therapeutics due to their high specificity and binding affinity for epitopes (the precise sites where an antibody attaches itself to an antigen, triggering an immune response). Since the therapeutic efficacy of antibodies is closely related to their target epitopes, epitope characterization

FOR IMMEDIATE RELEASE Credit: Twomey lab, Johns Hopkins Medicine FOR IMMEDIATE RELEASE By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius — nearly twice as cold as the coldest places in Antarctica — scientists at Johns

Bodybuilders and cellular mechanisms agree generating protein is a heavy lift. To complete the task, cells rely on complexes called spliceosomes. These molecular machines snip extra bits out of our genes’ RNA copies and piece together precise instructions for protein-building. When the splicing process goes

“[…] the identification of ubiquitin-conjugating enzymes like UBE2J1 and the innovative deployment of PROTAC-type androgen receptor degraders are crucial in combating prostate cancer and overcoming therapeutic resistance.” Credit: 2024 Li and Mu. “[…] the identification of ubiquitin-conjugating enzymes like UBE2J1 and the innovative deployment of

In the relentless fight against cancer, a new technology promises to shed light on how we track and understand the spread of this disease within the body. A research team from Northeastern University and Dartmouth College recently developed a remarkable tool called “diffuse in vivo flow cytometry”

Salvia miltiorrhiza, known as Danshen, is widely used in traditional Chinese medicine for treating cardiovascular diseases, cancer, and Alzheimer’s disease. The medicinal properties of Danshen are primarily attributed to its two major bioactive compounds: tanshinones and phenolic acids. Despite their importance, the genetic and regulatory

An international research team led by scientists from the University of Liège has discovered an interesting new therapeutic target for the treatment of melanoma resistant to targeted therapies. Inhibition of the VARS enzyme could prevent this therapeutic resistance by resensitising tumours resistant to these targeted

A study led by researchers from the University of Arizona Cancer Center at UArizona Health Sciences identified a biological mechanism that could lead to more effective treatments for breast cancer that has metastasized to the brain. Credit: Photo by Kris Hanning, UArizona Health Sciences Office of Communications

Both obesity and metabolic syndrome – a cluster of conditions like high blood pressure and high blood sugar – increase the risk of breast cancer, but in differing ways for different subtypes of the cancer. A University of Oklahoma researcher helped to lead a national

Restricting menthol flavor in cigarettes while making nicotine replacement therapy, such as a skin patch that can help ease withdrawal, more available and affordable has the potential to reduce socioeconomic disparities in tobacco use. Credit: CLAYTON METZ/Virginia Tech Restricting menthol flavor in cigarettes while making