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insilico-medicine-receives-ind-approval-from-fda-for-novel-mat2a-inhibitor-ism3412

Insilico Medicine receives IND approval from FDA for novel MAT2A inhibitor ISM3412

Clinical stage artificial intelligence (AI)-driven drug discovery company Insilico Medicine (“Insilico”) announces that it has received approval from the U.S. Food and Drug Administration (FDA) for its Investigational New Drug (IND) application for ISM3412, a small molecule inhibitor of MAT2A for the potential treatment of
microbiota-enterotoxigenic-bacteroides-fragilis-secreted-bft-1-promotes-breast-cancer-cell-stemness-and-chemoresistance-through-its-functional-receptor-nod1

Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

Tumor-resident microbiota in breast cancer promotes both the initiation and progression of cancer. However, the potential of targeting microbiota to enhance the efficacy of breast cancer treatment has not been comprehensively explored. In this study, researchers analyzed the microbial composition within breast tumors and identified a notable enrichment of ETBF in
international-dna-day-launch-for-hong-kong’s-moonshot-for-biology

International DNA Day launch for Hong Kong’s Moonshot for Biology

International DNA Day Launch for Hong Kong’s Moonshot for Biology Credit: Earth Biogenome Project: Hong Kong International DNA Day Launch for Hong Kong’s Moonshot for Biology The first emblematic species sequenced by the Hong Kong Biodiversity Genomics Consortium are published to coincide with International DNA
identifying-proteins-causally-related-to-covid-19,-healthspan-and-lifespan

Identifying proteins causally related to COVID-19, healthspan and lifespan

“[…] we identified multiple proteins affecting COVID-19 and aging.” Credit: 2024 Zhao et al. “[…] we identified multiple proteins affecting COVID-19 and aging.” BUFFALO, NY- April 24, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and
new-nanoprobes-developed-to-monitor-pd-l1-related-biological-processes

New nanoprobes developed to monitor PD-L1-related biological processes

Recently, the research group of Prof. HUANG Qing at Hefei Institutes of Physical Science, Chinese Academy of Sciences developed DNA-aptamer based surface enhanced Raman spectroscopy (SERS) probes for the study of immune system biomarker related bioprocesses in cancer cell metabolism. Credit: Muhammad Muhammad Recently, the
discovering-cancers-of-epigenetic-origin-without-dna-mutation

Discovering cancers of epigenetic origin without DNA mutation

A research team including scientists from the CNRS1 has discovered that cancer, one of the leading causes of death worldwide, can be caused entirely by epigenetic changes2, in other words, changes that contribute to how gene expression is regulated, and partly explain why, despite an
mini-colons-revolutionize-colorectal-cancer-research

Mini-colons revolutionize colorectal cancer research

As our battle against cancer rages on, the quest for more sophisticated and realistic models to study tumor development has never been more critical. Until now, research has relied on animal models and simplified cell culture methods, which are valuable but cannot fully capture the
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