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Among the cyclin-dependent kinases (CDKs), CDK8 and CDK19 regulate signal-induced, context-specific transcription reprogramming and play key roles in cell proliferation and differentiation. As previous studies have noted, the inhibition of CDK8/19 could suppress cancer cell proliferation and metastasis, thus posing a potential therapy for hematological

Acute liver failure (ALF) is a life-threatening clinical problem with limited treatment options. Administration of human umbilical cord mesenchymal stem cells (hUC-MSCs) may be a promising approach for ALF. This study aimed to explore the role of hUC-MSCs in the treatment of ALF and the

Cancer is a leading cause of death globally. One of the primary reasons why cancer is such a deadly disease is the ability of cancer cells to become drug-resistant. After decades of medical research, scientists came to understand that malignant tumors often harbor a special

A woman’s egg reserve is finite. Gonad-damaging therapies, such as certain chemotherapies, can therefore lead to infertility. One of the options for preserving fertility is the cryopreservation of ovarian tissue. This involves removing and freezing part of the ovary before a so-called gonadotoxic therapy. This

(Memphis, Tenn. – May 14, 2024) Deaths from cancer or infections can occur when available treatments are ineffective. Once turned on, pregnane X receptor (PXR) activates the expression of genes encoding enzymes that metabolize external chemicals, including drugs. This causes a significant drop in the effectiveness of chemotherapy, antivirals and other

“In this study, we first obtained evidence that, in mouse, aging primarily reduced the number of active sweat glands.” Credit: 2024 Zonnefeld et al. “In this study, we first obtained evidence that, in mouse, aging primarily reduced the number of active sweat glands.” BUFFALO, NY-

Hepatitis B virus (HBV) infection is a major risk factor for cirrhosis and liver cancer, and its treatment continues to be difficult. We previously demonstrated that a dopamine analog inhibited the packaging of pregenomic RNA into capsids. The present study aimed to determine the effect

Scientists have discovered a new insight into the genetic pathway of childhood cancer, offering new hope for tailored treatments. Credit: Image recorded by Dr. Ingrid Saldana Scientists have discovered a new insight into the genetic pathway of childhood cancer, offering new hope for tailored treatments.

SEATTLE — May 13, 2024 — Researchers at Fred Hutch Cancer Center have found in pre-clinical studies that an experimental gene therapy for genital and oral herpes removed 90% or more of the infection and suppressed how much virus can be released from an infected

Impact Journals is proud to participate at the Society for Scholarly Publishing (SSP) 46th Annual Meeting. Credit: Impact Jouranls Impact Journals is proud to participate at the Society for Scholarly Publishing (SSP) 46th Annual Meeting. BUFFALO, NY- May 13, 2024 – Impact Journals is proud to participate