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Researchers turn back the clock on cancer cells to offer new treatment paradigm

St. Jude Children’s Research Hospital scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state. Rhabdoid tumors are an aggressive cancer which is missing a key tumor suppressor protein. Findings showed that with the missing tumor suppressor, deleting or degrading the quality
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U of T researchers pinpoint key issue with common chemotherapy drug, identify new potential therapeutic targets for pancreatic cancer

Researchers at the University of Toronto’s Donnelly Centre for Cellular and Biomolecular Research have found two enzymes that work against the chemotherapy drug gemcitabine, preventing it from effectively treating pancreatic cancer. Credit: University of Toronto Researchers at the University of Toronto’s Donnelly Centre for Cellular and Biomolecular Research have
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Liver fibrosis, non-parenchymal cells, and the promise of exosome therapy

Liver disease is a major health concern, causing millions of deaths worldwide each year. One serious complication is liver fibrosis, scarring that can lead to liver failure. There is currently no effective treatment, but new research suggests promise for exosomes, tiny sacs released by cells.
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Beating by overheating: new strategy to combat cancer

Many new drugs inhibit the processes that cancer cells need to divide rapidly. So as to inhibit the cancer as a whole. But cancer cells have all sorts of workarounds to get around that effect. As a result, the tumor becomes unresponsive to treatment. Credit:
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